Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease

Figure 4 Protein tyrosine phosphatase non-receptor type 2 influences pathways involved in inflammatory bowel disease pathogenesis. A: Protein tyrosine phosphatase non-receptor type 2 (PTPN2) dephosphorylates JAK1/2 and STAT1/3/5 to control inflammatory cytokine signaling; B: PTPN2 promotes autophagy induction in response to invading bacteria; C: In epithelial cells PTPN2 protects against inflammation-induced barrier defects; D: In T cells, PTPN2 counteracts TCR associated kinases and thereby reduces the reaction towards cognate antigens. IL: Interleukin; JAK: Janus activated tyrosine kinase; Lck: Lymphocyte tyrosine kinase; NOD2: Nucleotide oligomerization domain containing protein 2; STAT: Signal transducer and activator of transcription; TCR: T cell antigen receptor.