Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease

Figure 1 Effect of loss of protein tyrosine phosphatase non-receptor type 2 on innate immune functions in the intestine. When protein tyrosine phosphatase non-receptor type 2 (PTPN2) is lost either by genetic deletion in the mouse or due to genetic variants in inflammatory bowel disease (IBD) patients, several aspects of innate immunity are affected, ultimately resulting in inflammation. Depicted are mechanisms that play pivotal roles in intestinal homeostasis. B: B cell; DC: Dendritic cell; IFN: Interferon; M: Macrophage; NO: Nitric oxide; T: T cell; TNF: Tumour necrosis factor; IL: Interleukin.