Cytomegalovirus in inflammatory bowel disease: A systematic review

Table 3 Prevalence by definition of cytomegalovirus-intestinal disease

Definition	Studies, n	Median	Range
HE or IHC1,2[38,44,53,54]	4	6%	2%-29%
HE[20,55]	2	9%	0%-17%
Tissue PCRquantitative > 10 copies/mg[56,57]	2	34%	30%-38%
Serology and (IHC or antigenemia or serum PCR or tissue PCR)[58]	1	6%	-
IHC[59]	1	0%	-
HE or IHC or tissue PCR[51]	1	33%	-
(Pp65 antigenemia or tissue PCRquantitative) and IHC and intestinal symptoms[39]	1	NA3	-
IHC positive when inflammation present[52]	1	1%	-
Total: 8	Total: 13

¹One study tested both before and after iv-steroid administration; ²No data on prevalence: definition is used as the gold standard to compare other diagnostics;

³No prevalence is reported in this study. PCR: Polymerase chain reaction; HE: Hematoxylin and eosin staining; IHC: Immunohistochemistry.