Antibody markers in the diagnosis of inflammatory bowel disease

Table 1 Target antigens and positive rates of antibody markers in inflammatory bowel disease

Antibody	Target antigen	Positive rate
		Crohn’s disease	Ulcerative colitis
Auto-antibody
pANCA	Nuclear histone 1 of polymorphonuclear leukocytes	10%-15%	60%-70%
Anti-pancreas antibody	A trypsin-sensitive protein in pancreatic juice	20%-40%	About 10%
Microbial antibody
ASCA	Mannan in the cell wall of bakers’ yeast	60%-70%	10%-15%
ACCA	Chitobioside in the cell wall of yeasts and bacteria	20%-40%	About 10%
ALCA	Laminaribioside in the cell wall of yeasts, fungi, wheat and algae	20%-40%	About 10%
AMCA	Mannobioside in the cell wall of microorganisms	-	-
Anti-OmpC antibody	Outer-membrane protein OmpC of Escherichia coli	55%	5%-10%
Anit-Cbir1 antibody	Flagellin, a component of the flagella of indigenous bacteria in colitis mice	55%	10%
Anti-I2 antibody	I2 component of Pseudomonas fluorescens in mononuclear cells in the intestinal mucosa in Crohn’s disease	55%	10%

pANCA: Perinuclear anti-neutrophil cytoplasmic antibody; ASCA: Anti-Saccharomyces cerevisia antibody; ACCA: Anti-chitobioside carbohydrate antibody; ALCA: Anti-laminaribioside carbohydrate antibody; AMCA: Anti-mannobioside carbohydrate antibody; OmpC: Outer-membrane porin C.