Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer

doi:10.3748/wjg.v22.i3.1224

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2016; 22(3): 1224-1235
Published online Jan 21, 2016. doi: 10.3748/wjg.v22.i3.1224

Table 1 Genetic alterations of group II p21-activated kinases in gastrointestinal cancers

Cancer location	PAKs	Alteration		Ref.
Cancer location	PAKs	Gene ampliﬁcation	Gene or protein overexpression
Oesophagus	PAK4		√	Ref.	[86]
Gallbladder	PAK4		√	[44]
Liver	PAK4		√	[64]
	PAK5		√	[21]
	PAK6		√	[67]
Pancreas	PAK4	√	√	[16,32,45,46]
Stomach	PAK4		√	[48,79]
Stomach	PAK5		√	[20]
Colon	PAK4	√		[47]
	PAK5		√	[56]
	PAK6		√	[95]

PAKs: p21-activated kinases.

Citation: Shao YG, Ning K, Li F. Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer. World J Gastroenterol 2016; 22(3): 1224-1235
URL: https://www.wjgnet.com/1007-9327/full/v22/i3/1224.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i3.1224