Smaller tumor size is associated with poor survival in T4b colon cancer

Table 1 Demographics of patients from the Surveillance, Epidemiology and End Results database with T4bN0-2M0 colon cancer, stratified by tumor size n (%)

Characteristic	Tumor size (cm)				P value
	Total (n = 1734)	≤4.0 (n = 274)	4.0-7.0 (n = 653)	≥7.0 (n = 807)
Median follow-up (mo)	43	33	43	50
IQR	15-107	12-92	17-105	14-114
Sex					0.395
Male	857 (49.4)	131 (47.8)	313 (47.9)	413 (51.2)
Female	877 (50.6)	143 (52.2)	340 (52.1)	394 (48.8)
Year of diagnosis					0.867
1988-1999	856 (49.4)	137 (50.0)	317 (48.5)	402 (49.8)
2000-2003	878 (50.6)	137 (50.0)	336 (51.5)	405 (50.2)
Age at diagnosis (yr)					0.330
≤ 60	785 (45.3)	130 (47.4)	281 (43.0)	374 (46.3)
> 60	949 (54.7)	144 (52.6)	372 (57.0)	433 (53.7)
Primary site					0.187
Right colon	1103 (63.6)	176 (64.2)	398 (60.9)	529 (65.6)
Left colon	631 (36.4)	98 (35.8)	255 (39.1)	278 (34.4)
Race					0.145
White	1386 (80.0)	212 (77.4)	530 (81.2)	644 (79.8)
Black	195 (11.2)	41 (15.0)	61 (9.3)	93 (11.5)
Other1	153 (8.8)	21 (7.6)	63 (9.5)	69 (8.7)
Histological type					0.016
Adenocarcinoma	1351 (77.9)	223 (81.4)	525 (80.4)	603 (74.7)
Mucinous adenocarcinoma	341 (19.7)	42 (15.3)	118 (18.1)	181 (22.4)
Signet-ring cell carcinoma	42 (2.4)	9 (3.3)	10 (1.5)	23 (2.9)
Pathology grade					0.001
High/Moderate	1158 (66.8)	189 (69.0)	466 (71.4)	503 (62.3)
Poor/Undifferentiated	576 (33.2)	85 (31.0)	187 (28.6)	304 (37.7)
N stage					0.001
N0	725 (41.8)	93 (34.0)	255 (39.0)	377 (46.7)
N1	460 (26.5)	74 (27.0)	188 (28.8)	198 (24.5)
N2	549 (31.7)	107 (39.0)	210 (32.2)	232 (28.8)
LNH					0.013
≤ 18	938 (54.1)	157 (57.3)	375 (57.4)	406 (50.3)
> 18	796 (45.9)	117 (42.6)	278 (42.6)	401 (49.7)

¹Includes Native American, Asian, Pacific Islander and Unknown. IQR: Interquartile range; LNH: Number of lymph nodes harvested.