Noninvasive models for assessment of liver fibrosis in patients with chronic hepatitis B virus infection

Table 2 Performance of noninvasive tests for diagnosis of significant fibrosis (≥ F2) and cirrhosis (F4) in hepatitis B virus-infected patients

Ref.	Year	n	Diagnosis of significant fibrosis				Diagnosis of cirrhosis
			AUC	Cutoff	Se/Sp (%)	PPV/NPV (%)	AUC	Cutoff	Se/Sp (%)	PPV/NPV (%)
Myers et al[68]	2003	209	0.78	< 0.2	89/52	43/92	NA
				> 0.8	18/99	92/75	NA
Zeng et al[52]	2005	373	0.84	< 3.0	94.8/44.1	70.1/86.1	0.84	> 8.7	35.3/95.2	91.1/51.6
Hui et al[51]	2005	235	0.79	≤ 0.15	51.5/84.6	74.5/66.7	NA
				> 0.5	16.2/97.4	84.6/57.1	NA
Zeng et al[19]	2013	198	NA				0.89	-1.03	88.0/88.1	68.7/96.1
Zeng et al[21]	2015	237	NA				0.87	-1.89	88.6/78.2	48.2/96.8
Seto et al[59]	2011	237	0.776	< 1.662	73.3/78.2	56.4/88.4	NA
Zhang et al[31]	2008	137	NA	NA	45.3/98.9	93.7/91.3	NA
Kim et al[55]	2007	346	NA				0.89	> 12	35.6/99.6	96.3/82.8
			NA					< 5	100/32	32/100
Chen et al[56]	2008	653	NA				0.907	0.1	92.8/74.1	52/97.1
Zhou et al[57]	2010	386	0.81	< 0.1	90.41/23.95	60.92/65.57	0.89	≥ 1.5	27.27/97.73	52.94/93.50
Taefi et al[62]	2015	152	NA				0.77	0.0880	82.7/61.0	52.4/87.1
Gümüşay et al[48]	2013	58	NA	NA	90/100	100/96.4	NA
Wang et al[42]	2013	349	0.856	0.75	56.5/94.1	92.9/61.5	0.956	0.9800	64.3/94.6	47.4/97.2
Lee et al[63]	2015	482	0.747	0.0625	72.3/67.7	93.4/58.0	0.811	0.0685	88.6/66.0	67.6/87.9
Liu et al[32]	2012	114	0.762	< 1.68	72.4/69.6	71.2/70.8	0.781	< 2.53	72.7/84.5	33.4/96.7
Mohamadnejad et al[66]	2006	276	0.91	4.72	97/52	26/99	NA
Fung et al[67]	2008	1268	0.85	6.87	82.1/73.5	67.6/85.9	0.89	8.93	78.0/85.7	69.6/90.3

AUC: Area under receiver operating curve; NA: Not available; NPV: Negative predictive value; PPV: Positive predictive value.