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Copyright ©The Author(s) 2016.
World J Gastroenterol. Aug 7, 2016; 22(29): 6610-6618
Published online Aug 7, 2016. doi: 10.3748/wjg.v22.i29.6610
Table 2 Related advances of noncoding RNAs in gastric cancer of this review
Type of ncRNAsExpressionPutative rolesPathwayTargetsRef.
miRNAs
miR-29cDownregulatedEarly event in gastric carcinogenesisUnknownITGB1[18]
miR-448, miR-15a, miR-485-5pDownregulatedSuppress proliferation, invasion or migrationUnknown[19-21]
miR-1290, miR-543UpregulatedPromote proliferation and metastasisUnknown[22,23]
miR-508-3pDownregulatedTumor suppressor effectNF-κB signalingNFKB1[24]
miR-544aUpregulatedRegulate EMT markersWnt signalingCDH1, AXIN2[25]
miR-375DownregulatedIncrease sensitivity to DPP treatmentUnknownERBB2, p-Akt[26]
miR-143DownregulatedInhibit autophagyUnknownGABARAPL1[27]
miR-27bDownregulatedInhibit HP-related proliferationWnt signalingUnknown[29]
lncRNAs
TUSC7Downregulatedp53-dependent tumor suppressive roleUnknownmiR-23b[43]
LSINCT5UpregulatedCorrelated with clinical parametersUnknownUnknown[44]
H19UpregulatedBiomarker, promote proliferationmiR-675[46,49]
HOTAIRUpregulatedBiomarker, inhibit apoptosis, promote invasion and metastasis[59,60]
MALAT1UpregulatedPromote migration and invasionUnknownEZH2[63]
Linc00152UpregulatedPromote cell proliferation, migration and invasion, cell cycle, and tumor growthPI3K/AktEGFR[64,65]
linc-POU3F3UpregulatedPromote distribution of Treg cellsTGF-βUnknown[66]
MIR31HGDownregulatedInhibit proliferationUnknownE2F1/p21[68]
piRNAs
piR-823DownregulatedTumor suppressive role[75]
piR-651UpregulatedPromote cell growth[76]
circRNAs
Hsa_circ_002059DownregulatedBiomarker[83]
circ-Foxo3UpregulatedCell cycle, promote proliferationp21/CDK2[84]
circ-ITCHDownregulatedmiRNA spongeWnt/β-catenin[85]