Pathophysiological role of guanylate-binding proteins in gastrointestinal diseases

Figure 1 Structure-function relationships of guanylate-binding protein-1. The guanylate binding protein-1 can be roughly divided into two domains: a compact globular domain carrying the GTPase activity at the N-terminus (blue) and a long helical domain comprised of α-helices at the C-terminus (grey), which are responsible for different protein functions.