Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer

doi:10.3748/wjg.v22.i28.6345

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Jul 28, 2016 (publication date) through Aug 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2016; 22(28): 6345-6361
Published online Jul 28, 2016. doi: 10.3748/wjg.v22.i28.6345

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Figure 1 Epidermal growth factor receptor and its downstream signaling pathway. Binding of ligands such as epidermal growth factor (EGF) to Epidermal growth factor receptor (EGFR) activates downstream Ras/ERK and PI3K/Akt pathways and regulates various physiological processes. The anti-EGFR monoclonal antibodies (mAbs) cetuximab and panitumumab block the activation of these pathways.

Citation: Sforza V, Martinelli E, Ciardiello F, Gambardella V, Napolitano S, Martini G, della Corte C, Cardone C, Ferrara ML, Reginelli A, Liguori G, Belli G, Troiani T. Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer. World J Gastroenterol 2016; 22(28): 6345-6361
URL: https://www.wjgnet.com/1007-9327/full/v22/i28/6345.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i28.6345