Specific CD8+ T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis

doi:10.3748/wjg.v22.i28.6469

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Jul 28, 2016 (publication date) through Nov 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2016; 22(28): 6469-6483
Published online Jul 28, 2016. doi: 10.3748/wjg.v22.i28.6469

Table 2 Overexpressed negative pathways in liver diseases

Disease	Overexpressed NR	Ligand for the overexpressed NR
HCC	CTLA-4[29], PD-1[12]	PD-L1[26], CD48[135]
CHB	CTLA-4[28], PD-1[25], LAG-3[117], Tim-3[129]	PD-L1[136]
CHC	CTLA-4[27], PD-1[24,105,106], LAG-3[116], 2B4[13,122], Tim-3[128]	PD-L1[44]

Overexpression of negative receptors on specific CD8⁺ T cells in different malignancies and overexpression of their cognate ligands in the liver tissue. CHB: Chronic hepatitis B; CHC: Chronic hepatitis C; HCC: Hepatocellular carcinoma; NR: Negative receptor.

Citation: Moreno-Cubero E, Larrubia JR. Specific CD8⁺ T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis. World J Gastroenterol 2016; 22(28): 6469-6483
URL: https://www.wjgnet.com/1007-9327/full/v22/i28/6469.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i28.6469