Re-evaluation of classical prognostic factors in resectable ductal adenocarcinoma of the pancreas

Table 6 Radicality of resection and survival

Ref.	Year	n	R1 definition	R1 rate (%)	Median OS	Survival model	HR (95% CI)	P value
					R0/R1 (mo)
Kooby et al[37]	2014	1399	1 mm	R0 (86)	21	Multivariable	1	0.009
				R1→R0 (5)	12		1.55 (1.11-2.16)	0.004
				R1 (9)	14		1.46 (1.13-1.90)
Konstantinidis et al[84]	2013	554	1 mm	157 (28)	35/14	Univariable	NR	< 0.001
Kimbrough et al[85]	2013	283	0 mm	76 (27)	22/15	Multivariable	NR	NS
Gnerlich et al[86]	2012	285	1 mm	97 (34)	22/16	Univariable	NR	0.010
Jamieson et al[11]	2010	148	1 mm	110 (74)	27/15	Multivariable	1.76 (1.15–2.28)	0.009
Van den Broeck et al[87]	2009	144	1 mm	48 (33)	24/12	Univariable	NR	< 0.001
Chang et al[88]	2009	365	0 mm	131 (36)	20/13	Multivariable	1.48 (1.15–1.89)	0.002
Campbell et al[50]	2009	163	1 mm	128 (79)	25/13	Multivariable	1.44 (0.90-2.32)	0.132
Westgaard et al[89]	2008	40	1 mm	18 (45)	16/11	Univariable	NR	0.300
Esposito et al[90]	2008	111	1 mm	84 (76)	NR	Univariable	NR	0.370
Raut et al[91]	2007	360	0 mm	61 (17)	28/22	Multivariable	NR	NS
Verbeke et al[92]	2006	26	1 mm	22 (85)	37/11	Multivariable	NR	0.790
Howard et al[93]	2006	226	0 mm	68 (30)	NR	Multivariable	1.39 (1.02-1.90)	0.030

NS: Not significant; OS: Overall survival.