Glucose deprivation induces chemoresistance in colorectal cancer cells by increasing ATF4 expression

Figure 8 Activating transcription factor 4 promotes the proliferation of colorectal cancer cells. A: We overexpressed ATF4 in LoVo and HCT116 cells and then inhibited ATF4 in these cells or their control cells, respectively; B: ATF4 overexpression enhanced the cell growth of LoVo and HCT116 cells; C: Silencing ATF4 expression inhibited the proliferation of ATF4-overexpressing cells in a dose- and time-dependent manner in LoVo and HCT116 cells. The CCK-8 assay was used to determine the cell growth rate. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, control vs ATF4. GD: Glucose deprivation; CRC: Colorectal cancer.