Glucose deprivation induces chemoresistance in colorectal cancer cells by increasing ATF4 expression

Figure 7 Inhibition of activating transcription factor 4 activity reintroduces drug sensitivity in activating transcription factor 4-overexpressing HCT116 cells. A: ATF4 knockdown increased sensitivity of HCT116-ATF4 cell to chemotherapy. The in vitro drug sensitivity was tested using the CCK-8 assay; B: ATF4 knockdown counteracted drug-induced apoptosis. The apoptotic rates were much higher in the shATF4-treated HCT116-ATF4 cells than in the control cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, vehicle vs shATF4.