Glucose deprivation induces chemoresistance in colorectal cancer cells by increasing ATF4 expression

Figure 4 Down-regulation of activating transcription factor 4 significantly reverses the glucose deprivation-induced resistance of HCT116 cells to chemotherapy. A: Silencing ATF4 expression using shATF4 in GD-treated LoVo and HCT116 cells; B: Depletion of ATF4 enhanced the sensitivity of HCT116 cells to LOHP and 5-FU. The in vitro drug sensitivity was tested using the CCK-8 assay. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, control vs GD. GD: Glucose deprivation.