Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia

Table 2 Risk of advanced colorectal neoplasia by single lifestyle factors n (%)

Variable	Total (n = 6315) % column1	Advanced colorectal neoplasia (n = 311) % row	Lifestyle point2	OR, (95%CI)3
Smoking4
Smoker	1988 (31)	140 (7)	0	1.00 (Ref)
Non-smoker	4311 (68)	171 (4)	1	0.53 (0.42-0.68)
Missing	16 (0)	0 (0)
Body Mass Index5
≥ 25.0	3658 (59)	205 (6)	0	1.00 (Ref)
< 25.0	2542 (41)	97 (4)	1	0.78 (0.60-1.01)
Missing	115 (2)	9 (8)
Physical activity 30 min, times per week
< 7	4480 (71)	238 (5)	0	1.00 (Ref)
≥ 7	1504 (24)	58 (4)	1	0.81 (0.60-1.09)
Missing	331 (5)	15 (5)
Alcohol, glasses per week
≤ 14 for male, ≤ 7 for female)	5525 (88)	264 (5)	1	0.63 (0.43-0.93)
Above	514 (8)	34 (7)	0	1.00 (Ref)
Missing	276 (4)	13 (5)
Fruits and vegetables, servings per day
< 3	4621 (73)	244 (5)	0	1.00 (Ref)
≥ 3	1446 (23)	52 (4)	0.5	0.93 (0.67-1.27)
Missing	248 (4)	15 (6)
Red and processed meat, servings per week
> 4	2059 (32)	108 (5)	0	1.00 (Ref)
≤ 4	4093 (65)	196 (5)	1	0.98 (0.76-1.26)
Missing	163 (3)	7 (4)
Fatty fish, servings per week
< 1	1257 (20)	78 (6)	0	1.00 (Ref)
≥ 1	5023 (79)	232 (5)	0.5	0.79 (0.60-1.05)
Missing	35 (1)	1 (3)
C-statistics				0.72 (0.69-0.75)

¹The number of replies may not sum to the total due to incomplete replies on the lifestyle questionnaire;

²One point for each lifestyle adherence, except only 1 point if adherence to both: fatty fish and fruits and vegetables;

³Models are adjusted for: age (continuously), screening arm (flexible sigmoidoscopy, fecal immunochemical), gender (women, men), center (Moss, Bærum), education (primary school, high school, university/college studies of minimum 2 yr) and whole meal bread. Lifestyle factors (Body Mass Index, smoking, alcohol, physical activity, fruits and vegetables, red and processed meat and fatty fish) were mutually adjusted for each other;

⁴18% current smoker, 14% ≤ 10 yr stopped, 28% > 10 yr stopped, 40% never smokers;

⁵43% had a Body Mass Index of 25.0-30.0; 16% had a Body Mass Index of > 30.0. Lifestyle characteristics, point for the lifestyle score, odds ratio (OR) and 95%CI between the single lifestyle factors and the risk of advanced colorectal neoplasia by multivariable logistic regression for participants in the lifestyle sub-study of the Bowel Cancer Screening in Norway - a pilot study.