Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma

doi:10.3748/wjg.v22.i27.6127

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2016; 22(27): 6127-6134
Published online Jul 21, 2016. doi: 10.3748/wjg.v22.i27.6127

Table 2 Experimental hepatocellular carcinoma animal models

Category		Inducing factor	Latency	Advantages	Disadvantages
Xenograft	Ectopic	Cancer cell line	Several weeks	Fast and easy modeling	Less clinical relevancy
Xenograft	Orthotopic	Cancer cell line	Several weeks	Easy detection of tumorigenesis	Only reflect the characteristics of the selected cells
Carcinogen-induced		DEN	5-10 mo	More clinical relevancy	Lengthy time and high cost to model
Genetically engineered		HBV-derived	12-24 mo	Uncovering the molecular mechanisms of hepatocarcinogenesis	Difficult to detect tumorigenesis
		HCV-derived	12-24 mo	Closely mimic the pathophysiological features of human HCC
		Oncogene-derived	Several weeks

DEN: Diethylnitrosamine; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus.

Citation: Kim KI, Chung HK, Park JH, Lee YJ, Kang JH. Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma. World J Gastroenterol 2016; 22(27): 6127-6134
URL: https://www.wjgnet.com/1007-9327/full/v22/i27/6127.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i27.6127