Impact of biliary stent-related events in patients diagnosed with advanced pancreatobiliary tumours receiving palliative chemotherapy

Table 5 Univariate and multivariable analysis looking for factors related with overall survival (Cox Regression)

Overall survival		Univariate analysis (Cox regression)		Multivariable analysis (Cox regression)
		HR (95%CI)	P-value	HR (95%CI)	P-value
Primary site	BTC	Ref		Ref
	Pancreas	1.6 (0.8-2.9)	0.153	1.5 (0.8-2.8)	0.205
Stage	Locally advanced	Ref		Ref
	Metastatic	1.6 (0.99-2.9)	0.067	1.8 (1.06-2.9)	0.029
ECOG-PS	0/1	Ref		Ref
	≥ 2	0.9 (0.5-1.6)	0.748	0.9 (0.5-1.6)	0.716
Stent-related event	No-SRE group	Ref		Ref
	SRE group	0.7 (0.4-1.1)	0.098	0.6 (0.4-1.01)	0.205

For assessment of factors with an impact on OS, variables considered of interest [such as site of primary tumour, stage, ECOG-PS and development of SRE (yes/no)] and those variables which showed statistically significant P-value in the univariate analysis were included in multivariable analysis. BTC: Biliary tract cancer; ECOG-PS: ECOG performance status.