Predictive factors of short term outcome after liver transplantation: A review

Table 1 Recent definitions of initial poor function and primary non function

Ref.	IPF	PNF
Broering et al[107]	ALT or AST or GDH > 2000 IU/L	Not-life sustaining graft leading to retransplantation or death within POD10
	FFP substituted for > 5 d postoperatively
Nanashima et al[108]	Two consecutive measurements within POD3:	IPF-induced retransplantation or death
	ALT or AST > 1500 IU/L
Heise et al[109]	Scoring system based on ALT, AST, bile output, Prothrombin activity on POD1-3-7-14 (Berlin score ranging from 4 to 8) Berlin C (IPF): 7-8
Tekin et al[110]	On POD7: AST > 1500 IU/L and PT > 20 s	Not-life sustaining graft leading to retransplantation or death within POD7
Ben-Ari et al[111]	AST or ALT > 2000 IU/L on POD2	Not-life sustaining graft leading to retransplantationor death within POD10
	INR > 1.6 on POD2-10
	Bilirubin > 10 mg/dL on POD2-10
Kremers et al[112]		ALT > 2500 IU/L
		Glucose < 60 mg/dL
		INR > 2.5
		bile flow < 50 mL/d
Pokorny et al[113]	On POD5: AST > 2500 IU/L or clotting support > 2 d	Not-life sustaining graft leading to retransplantationor death within POD7
Monbaliu et al[114]		Persisting encephalopathy
		Irreversible metabolic acidosis
		Profound hypoglicaemia
		Severe coagulopathy
		Insufficient bile production
		Increased AST
Cieślak et al[115]	Within POD1-7
	AST or ALT > 2500 IU/L or Prothrombin index < 50%
Dhillon et al[116]	[(AST+ALT)/2] on POD2:	IPF-induced retransplantationor death within POD7
	< 285 IU/L: good function
	285-986 IU/L: average function
	> 986 IU/L: IPF
Nemes et al[117]	On POD5: [Serum bilirubin (μmol/L)]/[Prothrombin (%)] > 1
Olthoff et al[81]	On POD1-7, one within:
	Bilirubin ≥ 10 mg/dL on POD7
	INR ≥ 1.6 on POD7
	ALT or AST > 2000 IU/L within POD7
Stockmann et al[59] and Lock et al[60]	Two LiMax readouts during the first 24 h: LiMax = 60-120 μg/kg per hour	Two LiMax readouts during the first 24 h: LiMax < 60 μg/kg per hour
Máthé et al[118]	Two consecutive measurements within POD3: ALT or AST > 1500 IU/L	IPF-induced retransplantation or death

Table freely extracted from Olthoff et al[81], Chen et al[12] and Pareja et al[106]. The mentioned studies are cited in chronological order. ALT: Alanine - aminotransferase; AST: Aspartate - aminotransferase; FFP: Fresh free plasma; GDH: Glutamate dehydrogenase; INR: International normalised ratio; LiMax: Liver maximal function Capacity; POD: Postoperative day; PT: Prothrombin time.