Copyright
©The Author(s) 2016.
World J Gastroenterol. Jul 7, 2016; 22(25): 5668-5677
Published online Jul 7, 2016. doi: 10.3748/wjg.v22.i25.5668
Published online Jul 7, 2016. doi: 10.3748/wjg.v22.i25.5668
Figure 1 RAS/RAF/MEK/ERK pathway and mechanisms of resistance to BRAF inhibition.
The figure above shows the MAPK pathway and the compensatory feedback loop activation (arrow) despite BRAF inhibition, resulting in the upstream reactivation of the MAPK pathway.
- Citation: Ahn DH, Ciombor KK, Mikhail S, Bekaii-Saab T. Genomic diversity of colorectal cancer: Changing landscape and emerging targets. World J Gastroenterol 2016; 22(25): 5668-5677
- URL: https://www.wjgnet.com/1007-9327/full/v22/i25/5668.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i25.5668