Gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy in the years 2000

Table 2 Clinical, laboratory and imaging factors associated with severe neutropenic enterocolitis

Factor	Outcome	Ref.
Previous therapy with cytarabine	Higher death rate	Rizzatti et al[22], 2010
Age > 16 yr	Worse response to medical therapy	McCarville et al[42], 2005
Presence of abdominal distention	Higher risk of death	Rizzatti et al[22], 2010
Presence of abdominal tenderness	Prolonged duration	McCarville et al[42], 2005
Presence of fever	Prolonged duration	McCarville et al[42], 2005
4 or more symptoms of enterocolitis	Higher risk of death	Rizzatti et al[22], 2010
Severe (absolute neutrophil count < 108/L) or prolonged (> 7 d) neutropenia	Disease progression	Jain et al[26], 2000
Duration of neutropenia	Prolonged duration	McCarville et al[42], 2005
Increased serum Interleukin-8 levels on the first day of clinical illness	Higher risk of admission in Intensive Care Unit	van de Wetering et al[55], 2008
Bowel wall tickness	Prolonged duration	Sundell et al[38], 2012
	Higher mortality rate	Cartoni et al[57], 2001
	Higher death rate	Rizzatti et al[22], 2010
	Prolonged duration	McCarville et al[42], 2005
Appendiceal thickening	Higher risk of serious complications	McCarville et al[56], 2004