Clinical analysis of patients with hepatocellular carcinoma recurrence after living-donor liver transplantation

Table 4 Factors related with survival rates after hepatocellular caricnoma recurrence

Factors	Univariate analysis	Multivariate analysis
	P value	Harzard ratio (95%CI)	P value
Age > 60 yr	0.124
Male sex	0.739
Etiology	0.291
MELD score > 15	0.153
GRWR < 1.0	0.658
Pre-transplant treatments	0.170
Tumor state at transplantation
AFP > 100	0.575
Beyond Milan criteria	0.245
Microvascular invasion	0.384
E-S grade III-IV	0.227
Time to recurrence < 12 mo	0.010	2.408 (1.007-5.756)	0.048
Multiple recurrence	< 0.001	3.438 (1.072-11.025)	0.038
Recurrence site
Liver	0.824
Lung	0.937
Bone	0.695
Brain	< 0.001	2.966 (0.565-15.583)	0.199
Palliative treatment for recurrent tumors	< 0.001	3.886 (1.591-9.490)	0.003

MELD: Model for end-stage liver disease; GRWR: Graft-to-recipient body weight ratio; AFP: Alpha-fetoprotein; E-S grade: Edmondson-Steiner grade.