miR-422a is an independent prognostic factor and functions as a potential tumor suppressor in colorectal cancer

Table 2 Univariate and multivariate analyses of overall survival in colorectal cancer patients

Variable	Category	Univariate analysis			Multivariate analysis
		HR	95%CI	P value	HR	95%CI	P value
Gender	Male vs Female	0.943	0.493-1.872	0.810
Age	≤ Median vs > Median	1.436	0.528-3.157	0.148
Tumor location	Colon vs Rectum	0.862	0.484-1.706	0.603
Tumor size	≤ 5 cm vs > 5 cm	1.093	0.568-2.194	0.873
Differentiation	Well and moderate vs Poor	1.018	0.462-2.180	0.160	0.986	0.486-2.006	0.074
Local invasion	T1-T2 vs T3-T4	1.682	1.020-2.628	0.011	1.460	0.746-2.632	0.482
Lymph node metastasis	Yes vs No	1.182	0.634-2.530	< 0.0011	1.262	0.584-2.680	0.306
TNM stage	I and II vs III	2.738	1.509-4.265	< 0.0011	2.942	1.426-4.378	0.0031
MiR-422a level	Low vs High	0.306	0.108-0.763	0.0011	0.568	0.245-1.082	0.0151

¹There was a significant difference between the two groups (P < 0.05).