Comprehensive mutation screening for 10 genes in Chinese patients suffering very early onset inflammatory bowel disease

Table 2 Clinical manifestations of very early-onset inflammatory bowel disease

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7	Patient 8	Patient 9	Patient 10	Patient 11	Patient 12	Patient 13
Gender	F	M	M	M	M	M	M	M	M	M	M	F	F
Age of onset (mo)	8	1	0.3	0.3	4	0.2	9	2	0.5	3	0.7	10	36
Height percentile	19%	1%	3%	1%	1%	1%	52%	1%	15%	1%	19%	16%	20%
Weight percentile	1%	1%	1%	1%	1%	20%	55%	13%	8%	15%	16%	60%	33%
Diarrhea (times/d)	> 10	7-8	> 10	10	5-10	5-6	7-8	2-4	7-8	No diarrhea	7-8	No diarrhea	2-3
Bloody stool	+	+	+	+	+	-	+	+	+	-	+	+	+
Infection	Sepsis	Pneumonia	No	Pneumonia, Clostridium difficile infection	Sepsis, oral candidiasis, fungemia, Clostridium difficile infection	Recurrent respiratory infection	No	No	No	Repeated fever of unknow origin	Oral candidiasis, gingivitis	No	No
Perianal lesion	Fistulae	No	No	Excrescence	Fistulae, abscess, excrescence	Fistulae, ulcer	No	No	No	No	Fistulae, abscess, excrescence	No	No
Clinical diagnosis	CD	CD	CD	CD	CD	CD	CD	CD	UC	CD	CD	UC	UC
Medication	GC, 6-MP	IFX, THD	GC, THD	GC, IFX1, THD	GC, IFX, THD	GC, IFX1	GC, IFX, MES	GC, IFX1, THD, 6-MP	GC, MES	GC, 6-MP, THD	GC, IFX, THD, 6-MP	MES	GC, MES
Clinical status	NR	PR	Died at 2 yr because of severe sepsis	PR	Died at 3 yr because of intestinal failure	NR	CR	PR	CR	CR	PR	CR	CR

¹Allergic to IFX. CD: Crohn's disease; UC: Ulcerative colitis; GC: Glucocorticoid; 6-MP: 6-mercaptopurine; IFX: Infliximab; THD: Thalidomide; MES: Mesalazine; NR: Non-remission; PR: Partial remission; CR: Complete remission.