Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma

Table 7 Stratified analysis on the association between single nucleotide polymorphism genotype and hepatocellular carcinoma risk according to smoking status

SNP	Smoking				Non-smoking
	Case	Control	OR (95%CI)1	P value1	Case	Control	OR (95%CI)1	P value1
rs2305952
TT	274	124	Reference		527	759	Reference
TC	77	32	1.05 (0.58-1.91)	0.87	132	206	0.94 (0.66-1.34)	0.75
CC	4	2	0.54 (0.06-4.97)	0.59	5	15	0.17 (0.05-0.56)	0.004a
TC/CC	81	34	1.01 (0.57-1.82)	0.96	137	221	0.84 (0.60-1.19)	0.33
rs515255
CC	145	53	Reference		263	358	Reference
TC	155	84	0.54 (0.32-0.93)	0.03a	314	469	0.81 (0.59-1.10)	0.17
TT	55	21	0.87 (0.41-1.85)	0.72	87	153	0.60 (0.39-0.94)	0.03a
TC/TT	210	105	0.61 (0.67-1.02)	0.06	401	622	0.75 (0.56-1.01)	0.06

¹OR and 95%CI after adjusting for age, sex, nationality, drinking, family history of hepatocellular carcinoma, and HBV infection.

^aP < 0.05 was considered statistically significant. OR: Odds ratio; CI: Confidence interval; SNPs: Single nucleotide polymorphisms.