Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma

Table 4 Associations between single nucleotide polymorphisms with the risk of hepatocellular carcinoma

SNP	Genotype	OR (95%CI)1	P value1	OR (95%CI)2	P value2
rs2305952	TT	Reference		Reference
	TC	0.97 (0.79-1.19)	0.76	0.97 (0.72-1.32)	0.85
	CC	0.58 (0.26-1.32)	0.19	0.22 (0.08-0.63)	0.01a
	TC/CC	0.94 (0.77-1.16)	0.57	0.89 (0.66-1.19)	0.43
rs2425675	GG	Reference		Reference
	AG	1.07 (0.89-1.28)	0.49	1.92 (0.71-1.20)	0.54
	AA	1.12 (0.71-1.76)	0.63	0.97 (0.51-1.85)	0.93
	AG/AA	1.07 (0.90-1.28)	0.44	0.93 (0.72-1.20)	0.56
rs3088440	GG	Reference		Reference
	GA	0.90 (0.74-1.09)	0.29	1.02 (0.76-1.35)	0.92
	AA	0.87 (0.48-1.58)	0.64	1.46 (0.62-3.44)	0.38
	GA/AA	0.90 (0.74-1.09)	0.26	1.04 (0.79-1.37)	0.77
rs3917148	AA	Reference		Reference
	CA	1.13 (0.92-1.39)	0.24	1.18 (0.88-1.59)	0.28
	CC	0.71 (0.35-1.42)	0.33	1.05 (0.41-2.68)	0.92
	CA/CC	1.10 (0.90-1.34)	0.37	1.17 (0.88-1.56)	0.29
rs3929	GG	Reference		Reference
	GC	0.98 (0.82-1.18)	0.84	0.97 (0.75-1.26)	0.82
	CC	1.03 (0.69-1.53)	0.88	1.39 (0.80-2.42)	0.25
	GC/CC	0.99 (0.83-1.18)	0.89	1.02 (0.79-1.30)	0.90
rs6987652	GG	Reference		Reference
	AG	1.06 (0.87-1.29)	0.60	0.92 (0.69-1.23)	0.59
	AA	1.14 (0.65-1.99)	0.66	1.26 (0.55-2.88)	0.59
	AG/AA	1.06 (0.88-1.29)	0.54	0.95 (0.72-1.25)	0.71
rs11556090	AA	Reference		Reference
	AG	1.23 (1.02-1.47)	0.03	1.11 (0.85-1.44)	0.44
	GG	1.26 (0.82-1.94)	0.29	1.02 (0.54-1.91)	0.96
	AG/GG	1.23 (1.03-1.47)	0.02	1.10 (0.85-1.42)	0.47
rs17006625	AA	Reference		Reference
	AG	1.09 (0.91-1.30)	0.35	1.07 (0.83-1.38)	0.61
	GG	1.33 (0.95-1.86)	0.10	1.64 (1.01-2.64)	0.04a
	AG/GG	1.12 (0.95-1.33)	0.18	1.14 (0.89-1.46)	0.29
rs2070215	AA	Reference		Reference
	AG	1.05 (0.88-1.26)	0.58	0.95 (0.73-1.24)	0.71
	GG	1.49 (1.12-1.98)	0.01	1.39 (0.93-2.08)	0.11
	AG/GG	1.13 (0.95-1.34)	0.16	1.03 (0.81-1.32)	0.81
rs2261360	CC	Reference		Reference
	CA	0.92 (0.77-1.10)	0.35	0.84 (0.64-1.09)	0.19
	AA	0.84 (0.65-1.10)	0.21	0.89 (0.60-1.31)	0.55
	CA/AA	0.90 (0.76-1.07)	0.22	0.85 (0.66-1.09)	0.19
rs3734166	AA	Reference		Reference
	GA	0.89 (0.74-1.07)	0.22	0.92 (0.71-1.21)	0.56
	GG	0.66 (0.50-0.86)	0.002	0.86 (0.59-1.25)	0.43
	GA/GG	0.83 (0.70-0.99)	0.04	0.91 (0.71-1.17)	0.45
rs4858770	CC	Reference		Reference
	CT	0.94 (0.78-1.12)	0.47	0.96 (0.74-1.24)	0.74
	TT	0.75 (0.57-0.98)	0.04	0.80 (0.54-1.20)	0.28
	CT/TT	0.89 (0.75-1.06)	0.19	0.92 (0.72-1.18)	0.51
rs515255	CC	Reference		Reference
	TC	0.85 (0.71-1.03)	0.09	0.73 (0.56-0.96)	0.02a
	TT	0.82 (0.63-1.07)	0.14	0.67 (0.46-0.97)	0.04a
	TC/TT	0.85 (0.71-1.01)	0.06	0.72 (0.56-0.92)	0.01a
rs8025774	CC	Reference		Reference
	CT	1.01 (0.83-1.22)	0.95	0.95 (0.72-1.27)	0.74
	TT	0.80 (0.63-1.02)	0.08	0.94 (0.66-1.32)	0.71
	CT/TT	0.94 (0.78-1.13)	0.52	0.95 (0.73-1.24)	0.69

¹OR and 95%CI without adjusting for confounding factors;

²OR and 95%CI after adjusting for age, sex, nationality, smoking, drinking, family history of hepatocellular carcinoma, and HBV infection.

^aP < 0.05 was considered statistically significant. OR: Odds ratio; CI: Confidence interval; SNPs: Single nucleotide polymorphisms.