Effects of sphincter of Oddi motility on the formation of cholesterol gallstones

Table 4 Changes in VIP, gastrin and CCK-8 in the process of cholesterol stone formation (pg/mL)

Group	3-wk	6-wk	9-wk	12-wk
VIP
Control	9.36 ± 2.72	9.30 ± 8.91	6.91 ± 3.14	8.39 ± 0.99
Cholesterol stone	11.83 ± 3.57	7.08 ± 2.31	31.20 ± 7.78a	22.15 ± 2.87c
Gastrin
Control	17.83 ± 2.35	18.56 ± 5.77	17.42 ± 6.39	19.41 ± 4.58
Cholesterol stone	0.08 ± 0.03c	4.18 ± 2.87	2.16 ± 0.44a	18.92 ± 8.37
CCK-8
Control	1970.33 ± 439.82	2353.32 ± 13.18	2100.27 ± 29.70	2107.77 ± 171.70
Cholesterol stone	2214.61 ± 174.96	2044.18 ± 147.03	2034.75 ± 138.39	2042.61 ± 265.01

^aP < 0.05,

^cP < 0.01 vs the control group. VIP: Vasoactive intestinal peptide; CCK-8: Cholecystokinin octapeptide.