Association of HER2 status with prognosis in gastric cancer patients undergoing R0 resection: A large-scale multicenter study in China

Table 3 Adjusted¹ hazards ratios for the association between human epidermal growth receptor 2 status and gastric cancer stratified by age, gender, tumor location and TNM stage

Characteristic	DFS		OS
	HR (95%CI)1	Pinteraction value	HR (95%CI)1	Pinteraction value
Age		< 0.001		0.003
< 60 yr	1.00 (0.69-1.44)		1.09 (0.74-1.60)
≥ 60 yr	1.32 (1.02-1.71)		1.28 (0.98-1.68)
Gender		0.116		0.070
Female	1.10 (0.70-1.73)		1.18 (0.95-1.47)
Male	1.21 (0.96-1.53)		1.20 (0.88-1.64)
Tumor location		0.268		0.303
Non-cardia	1.22 (0.91-1.63)		1.20 (0.88-1.64)
Cardia	1.18 (0.87-1.58)		1.21 (0.88-1.65)
TNM stage		0.037		0.041
I	1.86 (0.98-3.50)		2.03 (0.97-4.23)
II	1.55 (0.94-2.55)		1.75 (1.04-2.94)
III	1.06 (0.83-1.36)		1.03 (0.79-1.33)

¹Adjusted HRs and 95%CIs are calculated using models stratified by age, gender, location and TNM stage, with additional adjustment for ethnic, history of family cancer, tumor embolus, neural invasion, adjuvant chemotherapy and adjuvant radiotherapy. Number of observations in the original data set = 1562. Number of observations used = 1313, owing to the missing value occurring in family history of cancer (249). DFS: Disease free survival; OS: Overall survival; TNM: Tumor-node-metastasis.