Association of HER2 status with prognosis in gastric cancer patients undergoing R0 resection: A large-scale multicenter study in China

Table 1 Baseline and clinicopathological characteristics among gastric cancer patients with different human epidermal growth receptor 2 status n (%)

Characteristic	HER2 status		Total	χ2	P value1
	Negative (-) n = 1014	Positive (+) n = 548
Age
Median (range)	60 (21-82)	60 (20-84)	59 (20-84)
< 60 yr	504 (63.72)	287 (36.28)	791 (50.64)	1.012	0.314
≥ 60 yr	510 (66.15)	261 (33.85)	771 (49.36)
Gender				8.288	0.004
Female	274 (70.98)	112 (29.02)	386 (24.71)
Male	740 (62.93)	436 (37.07)	1176 (75.29)
Minority				11.518	< 0.001
Han population	989 (65.71)	516 (34.29)	1505 (96.35)
Others	25 (43.86)	32 (56.14)	57 (3.65)
History of familial cancer				0.144	0.705
No	890 (76.99)	266 (23.01)	1156 (88.64)
Yes	123 (78.34)	34 (21.66)	157 (11.96)
Tumor location				10.357	0.001
Non-cardia	624 (62.03)	382 (37.97)	1006 (64.40)
Cardia	390 (70.14)	166 (29.86)	556 (35.60)
Histological grade				37.822	< 0.001
High differentiation	31 (40.79)	45 (59.21)	76 (4.87)
Moderate differentiation	203 (61.89)	125 (38.11)	328 (21.00)
Low differentiation or	762 (68.40)	352 (31.60)	1114 (71.32)
Signet-ring cell cancer
Early and unreported	18 (40.91)	26 (59.09)	44 (2.82)
TNM stage				21.640	< 0.001
I	207 (55.20)	168 (44.80)	375 (24.01)
II	215 (65.55)	113 (34.45)	328 (21.00)
III	592 (68.92)	267 (31.08)	859 (54.99)
Tumor embolus				0.034	0.954
No	761 (64.88)	412 (35.12)	1173 (75.10)
Yes	253 (65.04)	136 (34.96)	389 (24.90)
Neural invasion				3.054	0.081
No	877 (65.79)	456 (34.21)	1333 (85.34)
Yes	137 (59.83)	92 (40.17)	229 (14.66)
Adjuvant chemotherapy				2.872	0.090
No	423 (62.57)	253 (37.43)	676 (43.28)
Yes	591 (66.70)	295 (33.30)	886 (56.72)
Adjuvant radiotherapy				6.396	0.011
No	936 (64.11)	524 (35.89)	1460 (93.47)
Yes	78 (76.47)	24 (23.53)	102 (6.53)

¹The parametric P value is calculated by t-test for numerical covariates and χ² test for categorical covariates. Number of observations in the original data set = 1562. Number of observations used = 1313, owing to the missing value occurring in family history of cancer (249). HER2: Human epidermal growth receptor 2.