Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma

doi:10.3748/wjg.v22.i23.5393

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2016; 22(23): 5393-5399
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5393

Table 2 Univariate analysis of risk factors for hepatocellular carcinoma development

Variables	RR (95%CI)	P value
Genomic changes
C1653T in X region	1.583 (0.176-14.210)	NS
T1753V in X region	17.565 (1.956-157.737)	< 0.01
A1762T/G1764A in BCP	30.512 (0.004-230706)	NS
G1896A in PC	5.765 (0.519-64.076)	NS
Pre-S deletion	2.491 (0.502-12.370)	NS
Clinical characteristics
Age > 50 yr	57.5 (0.035-93428)	NS
Male	27.3 (0.001-547718)	NS
ALT > 80 IU/L	0.55 (0.091-3.29)	NS
PT ≤ 70 %	4.12 (0.682-24.845)	NS
Serum AFP > 200 ng/mL	0.044 (0.00-209046)	NS
HBeAg positive	0.034 (0.00-360.724)	NS
HBV DNA > 10⁵ copies/mL	0.741 (0.123-4.452)	NS

RR: Relative risk; CI: Confidence interval; NS: Not significant; BCP: Basal core promoter; PC: Precore; ALT: Alanine aminotransferase; PT: Prothrombin time; AFP: α-fetoprotein; HBeAg: Hepatitis B e antigen.

Citation: Lee D, Lyu H, Chung YH, Kim JA, Mathews P, Jaffee E, Zheng L, Yu E, Lee YJ, Ryu SH. Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma. World J Gastroenterol 2016; 22(23): 5393-5399
URL: https://www.wjgnet.com/1007-9327/full/v22/i23/5393.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i23.5393