Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients

Figure 1 Study design and visceral sensitivity evaluation. A: Schematic flow chart showing the treatment and co-housing relationship of involved rats. For each code, such as “B8”, the character “B” indicates the nest and number 8 indicates the number of rats. They were cohoused until “B4”, which indicates that four of them were randomly chosen and cohoused together. The asterisk indicates fecal samples that failed to return the sequencing data; B: Abdominal withdrawal reaction (AWR) score in response to the graded colorectal distention (CRD); C: Visceromotor response (VMR) score in response to graded CRD. MS: Maternal separation; MS_D: MS early death; pTNBS: TNBS post-inflammatory.