Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-II expression on dendritic cells in chronic hepatitis C infection

Figure 5 Interactions between different interferon stimulatory genes and negative regulatory genes of immune system. Using string software, possible interaction pathways between different Interferon Stimulatory genes and Negative regulatory genes were drawn. Negative regulators such as SOCS, PIAS when upregulated results in the inhibition of STAT and GBP genes which in turn result in the induction of transcription of many genes involved in innate immunity and interferon signaling such as IRF7, IRF9 and ISG20. ISG: Interferon stimulatory genes.