Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss

Table 3 Changes of expression level of serum hormones

Group		Ghrelin (ng/mL)	Leptin (ng/mL)	NPY (pg/mL)	5-HT (ng/mL)	CCK (pg/mL)	MTL (pg/mL)	GAS (pg/mL)
MG	Baseline	4.62 ± 1.53	9.87 ± 4.65	107.52 ± 26.21	237.83 ± 56.94	392.36 ± 27.21	32.53 ± 6.28	56.37 ± 21.15
	4 wk	6.02 ± 3.43ace	7.25 ± 3.47ace	114.56 ± 25.10a	208.47 ± 52.48a	221.69 ± 23.77a	49.46 ± 6.10ace	48.37 ± 11.93ace
	8 wk	8.97 ± 3.64ace	4.03 ± 2.77ace	149.27 ± 39.53ace	176.92 ± 53.38ace	183.85 ± 27.65ace	66.28 ± 3.97ace	41.61 ± 10.52ace
PG	Baseline	4.68 ± 2.12	9.07 ± 4.65	105.12 ± 29.52	232.83 ± 50.94	390.82 ± 27.54	31.98 ± 9.34	54.98 ± 15.24
	4 wk	5.12 ± 2.23	8.75 ± 3.05	112.31 ± 15.10a	215.32 ± 24.91a	291.57 ± 31.76a	40.37 ± 8.23a	52.37 ± 12.97
	8 wk	6.01 ± 3.27a	8.25 ± 2.13	114.27 ± 28.53a	210.17 ± 49.17a	283.85 ± 47.15a	53.28 ± 6.84a	48.61 ± 11.17a
CG	Baseline	4.89 ± 2.47	8.87 ± 2.65	104.93 ± 17.95	235.81 ± 61.82	391.75 ± 24.96	36.26 ± 6.22	54.23 ± 26.83
	4 wk	5.48 ± 2.15	8.32 ± 3.57	108.92 ± 29.64	211.26 ± 46.28	224.67 ± 23.45	43.92 ± 7.24	49.21 ± 12.15
	8 wk	6.93 ± 2.35	8.02 ± 1.45	121.43 ± 13.92	208.95 ± 38.29	303.12 ± 26.76	55.53 ± 5.98	43.34 ± 13.72

^aP < 0.05 vs baseline in the same group;

^cP < 0.05, MG vs PG;

^eP < 0.05, MG vs CG. MG: Mirtazapine group; PG: Paroxetine group; CG: Conventional group; NPY: Neuropeptide Y; 5-HT: 5-hydroxytryptamine; CCK: Cholecystokinin; MTL: Motilin; GAS: Gastrin.