Meta-Analysis
Copyright ©The Author(s) 2016.
World J Gastroenterol. Jun 7, 2016; 22(21): 5122-5131
Published online Jun 7, 2016. doi: 10.3748/wjg.v22.i21.5122
Table 2 Study characteristics
StudyCountryStudy designn(active: control)Transit timeoutcome, methodProbiotic strainDaily dosage(109 CFU)Delivery methodTreatmentduration(d)
Agrawal et al[14], 2009United KingdomParallel groups17:17CTT, radiopaque markersB. lactis DN-173 01025Active: Yogurt + probiotic28
Control: Nonfermented milk-based product
Bartram et al[15], 1994GermanyCross-over12OATT, radiopaque markersB. longum> 0.5Active: Yogurt with 2.5 g lactulose + probiotic21
Control: Yogurt
Bazzocchi et al[25], 2014ItalyParallel groups19:12TITT, radiopaque markersL. plantarum, L. acidophilus, L. rhamnosus, B. longum, B. breve-Active: Sachet with psyllium+probiotic56
Control: Sachet with 2.8 g maltodextrin
Bouvier et al[16], 2001FranceParallel groups36:36CTT, radiopaque markersB. lactis DN-173 01097.5Active: Probiotic fermented milk11
Control: Heat-treated probiotic fermented milk
Holma et al[17], 2010FinlandParallel groups12:10TITT, radiopaque markersL. rhamnosus GG20Active: Buttermilk + probiotic and white wheat bread21
Control: White wheat bread
Hongisto et al[18], 2006FinlandParallel groups16:14TITT, radiopaque markersL. rhamnosus GG15Active: Yogurt + probiotic and low fiber toast21
Control: Low fiber toast
Krammer et al[24], 2011GermanyParallel groups12:12CTT, radiopaque markersL. casei Shirota6.5Active: Probiotic fermented milk drink28
Control: Nonfermented milk drink
Magro et al[26], 2014BrazilParallel groups26:21CTT, radiopaque markersL. acidophilus NCFM, B. lactis HN0192Active: Yogurt + polydextrose + probiotic Control: Yogurt14
Malpeli et al[19], 2012ArgentinaCross-over83OCTT, carmine red dyeB. lactis BB122-20Active: Yogurt with 0.625 g inulin and oligofructose + probiotic15
L. casei CRL 4312-12Control: Yogurt
Marteau et al[20], 2002FranceCross-over32CTT, radiopaque markersB. lactis DN-173 01018.75Active: Yogurt + probiotic10
Control: Yogurt
Merenstein et al[27], 2014United StatesCrossover68CTT, radiopaque markersB. animalis ssp. lactis Bf-620-56Active: Yogurt + probiotic14
Control: Yogurt
Rosenfeldt et al[21], 2003aDenmarkCross-over13GTT, radiopaque markersL. rhamnosus 19070-220Active: Freeze-dried powder + probiotic18
L. reuteri DSM 1224620Control: Skimmed milk powder w/dextrose
Rosenfeldt et al[21], 2003bDenmarkCross-over13GTT, radiopaque markersL. casei subsp. alactus CHCC 313720Active: Freeze-dried powder + probiotic18
L. delbrueckii subsp. lactis CHCC 232920Control: Skimmed milk powder w/dextrose
L. rhamnosus GG20
Sairanen et al[22], 2007FinlandParallel groups22:20CTT, radiopaque markersB. longum BB536, B. lactis 4202.4-181Active: Probiotic fermented milk21
L. acidophilus 1450.48Control: Fermented milk
Tulk et al[28], 2013CanadaCrossover65GTT, carmine red/carbon black capsulesB. lactis Bb12, L. acidophilus La5, L. casei CRL4312Active: Yogurt + probiotic + inulin15
Control: Yogurt
Waller et al[23], 2011aUnited StatesParallel groups33:34WGTT; radiopaque markersB. lactis HN0191.8Active: Capsule, maltodextrin, probiotic14
Control: Capsule, maltodextrin
Waller et al[23], 2011bUnited StatesParallel groups33:34WGTT; radiopaque markersB. lactis HN01917.2Active: Capsule, maltodextrin, probiotic14
Control: Capsule, maltodextrin