Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer

doi:10.3748/wjg.v22.i21.5060

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2016; 22(21): 5060-5067
Published online Jun 7, 2016. doi: 10.3748/wjg.v22.i21.5060

Table 2 Dose-dependent association between gastric cancer risk and serum catalase and alkyl hydroperoxide antibodies levels in study subjects n (%)

All subjects					H. pylori positive subjects					H. pylori negative subjects
Antibody level (OD)¹	Case	Control	OR (95%CI)²	P value for trend	Antibody level (OD)	Case	Control	OR (95%CI)²	P value for trend	Antibody level (OD)	Case	Control	OR (95%CI)²	P value for trend
KatA
≤ 0.4187	167 (71.98)	66 (25.0)	1.0 (Reference)	< 0.001	≤ 0.4152	92 (69.70)	29 (24.58)	1.0 (Reference)	< 0.001	≤ 0.4167	66 (74.16)	32 (24.58)	1.0 (Reference)	< 0.001
0.4187-0.5313	36 (15.52)	66 (25.0)	4.25 (2.49-7.27)		0.4152-0.5133	23 (17.42)	30 (25.42)	3.79 (1.78-8.06)		0.4167-0.5568	9 (10.11)	33 (25.42)	6.67 (2.70-16.51)
0.5313-0.6799	18 (7.76)	66 (25.0)	9.95 (5.05-19.62)		0.5133-0.6692	9 (6.82)	30 (25.42)	9.69 (3.81-24.70)		0.5568-0.6824	11 (21.36)	33 (25.42)	7.00 (2.68-18.30)
> 0.6799	11 (4.74)	66 (25.0)	15.85 (6.97-36.06)		> 0.6692	8 (6.06)	29 (24.58)	16.55 (5.51-49.76)		> 0.6824	3 (3.39)	32 (24.58)	19.89 (4.32-91.70)
AhpC
≤ 0.2168	88 (37.93)	66 (25.00)	1.0 (Reference)	< 0.001	≤ 0.2182	51 (38.64)	29 (24.58)	1.0 (Reference)	< 0.001	≤ 0.2110	31 (34.83)	32 (24.58)	1.0 (Reference)	< 0.001
0.2168-0.3265	69 (29.74)	66 (25.00)	1.26 (0.76-2.11)		0.2182-0.3433	41 (31.06)	30 (25.42)	1.10 (0.54-2.25)		0.2110-0.3310	29 (32.58)	33 (25.42)	1.44 (0.69-3.00)
0.3265-0.4888	49 (21.12)	66 (25.00)	1.41 (0.82-2.43)		0.3433-0.4908	28 (21.21)	30 (25.42)	1.54 (0.70-3.38)		0.3310-0.4948	16 (17.98)	33 (25.42)	1.83 (0.80-4.23)
> 0.4888	26 (11.21)	66 (25.00)	3.54 (1.84-6.82)		> 0.4908	12 (9.09)	29 (24.58)	3.40 (1.32-8.73)		> 0.4948	13 (14.61)	32 (24.58)	3.33 (1.31-8.46)

¹Serum positivity for the antibodies to KatA and AhpC was categorized by quartiles of antibody levels in controls;

²Adjusted for age, sex, family history of gastric cancer, smoking, and alcohol consumption. H. pylori: Helicobacter pylori; KatA: Catalase; AhpC: Alkyl hydroperoxide reductase.

Citation: Zhang B, Li HL, Fan Q, Guo F, Ren XY, Zhou HB, Zhu JW, Zhao YS, Tian WJ. Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer. World J Gastroenterol 2016; 22(21): 5060-5067
URL: https://www.wjgnet.com/1007-9327/full/v22/i21/5060.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i21.5060