Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer

doi:10.3748/wjg.v22.i21.5060

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 21

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (8141)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-4) series, Tables (1-3) series.

Item

Count

PDF

493

WORD

284

HTML

3750

Figures (1-4)

303

Tables (1-3)

200

Sum=5030

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1049

Download

2062

Sum=3111

Jun 7, 2016 (publication date) through Dec 22, 2024

Times Cited of This Article

Times Cited (1)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Gastroenterol. Jun 7, 2016; 22(21): 5060-5067
Published online Jun 7, 2016. doi: 10.3748/wjg.v22.i21.5060

Table 2 Dose-dependent association between gastric cancer risk and serum catalase and alkyl hydroperoxide antibodies levels in study subjects n (%)

All subjects					H. pylori positive subjects					H. pylori negative subjects
Antibody level (OD)¹	Case	Control	OR (95%CI)²	P value for trend	Antibody level (OD)	Case	Control	OR (95%CI)²	P value for trend	Antibody level (OD)	Case	Control	OR (95%CI)²	P value for trend
KatA
≤ 0.4187	167 (71.98)	66 (25.0)	1.0 (Reference)	< 0.001	≤ 0.4152	92 (69.70)	29 (24.58)	1.0 (Reference)	< 0.001	≤ 0.4167	66 (74.16)	32 (24.58)	1.0 (Reference)	< 0.001
0.4187-0.5313	36 (15.52)	66 (25.0)	4.25 (2.49-7.27)		0.4152-0.5133	23 (17.42)	30 (25.42)	3.79 (1.78-8.06)		0.4167-0.5568	9 (10.11)	33 (25.42)	6.67 (2.70-16.51)
0.5313-0.6799	18 (7.76)	66 (25.0)	9.95 (5.05-19.62)		0.5133-0.6692	9 (6.82)	30 (25.42)	9.69 (3.81-24.70)		0.5568-0.6824	11 (21.36)	33 (25.42)	7.00 (2.68-18.30)
> 0.6799	11 (4.74)	66 (25.0)	15.85 (6.97-36.06)		> 0.6692	8 (6.06)	29 (24.58)	16.55 (5.51-49.76)		> 0.6824	3 (3.39)	32 (24.58)	19.89 (4.32-91.70)
AhpC
≤ 0.2168	88 (37.93)	66 (25.00)	1.0 (Reference)	< 0.001	≤ 0.2182	51 (38.64)	29 (24.58)	1.0 (Reference)	< 0.001	≤ 0.2110	31 (34.83)	32 (24.58)	1.0 (Reference)	< 0.001
0.2168-0.3265	69 (29.74)	66 (25.00)	1.26 (0.76-2.11)		0.2182-0.3433	41 (31.06)	30 (25.42)	1.10 (0.54-2.25)		0.2110-0.3310	29 (32.58)	33 (25.42)	1.44 (0.69-3.00)
0.3265-0.4888	49 (21.12)	66 (25.00)	1.41 (0.82-2.43)		0.3433-0.4908	28 (21.21)	30 (25.42)	1.54 (0.70-3.38)		0.3310-0.4948	16 (17.98)	33 (25.42)	1.83 (0.80-4.23)
> 0.4888	26 (11.21)	66 (25.00)	3.54 (1.84-6.82)		> 0.4908	12 (9.09)	29 (24.58)	3.40 (1.32-8.73)		> 0.4948	13 (14.61)	32 (24.58)	3.33 (1.31-8.46)

¹Serum positivity for the antibodies to KatA and AhpC was categorized by quartiles of antibody levels in controls;

²Adjusted for age, sex, family history of gastric cancer, smoking, and alcohol consumption. H. pylori: Helicobacter pylori; KatA: Catalase; AhpC: Alkyl hydroperoxide reductase.

Citation: Zhang B, Li HL, Fan Q, Guo F, Ren XY, Zhou HB, Zhu JW, Zhao YS, Tian WJ. Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer. World J Gastroenterol 2016; 22(21): 5060-5067
URL: https://www.wjgnet.com/1007-9327/full/v22/i21/5060.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i21.5060