How important is donor age in liver transplantation?

Table 3 Review of cellular and molecular mechanisms suggested to be implicated in the loss of aged liver’s regenerative capacity

Mechanism	Ref.
Telomere shortening	Takubo et al[55]
	Aikata et al[56]
	Aini et al[57]
Transcriptional and post-transcriptional modifications	Timchenko[60]
	Wang et al[61]
Hepatocelullar response to growth factors	Schmucker[53]
	Wang et al[61]
Pseudo-capillarization	Furrer et al[62]
Decline of progenitor cell populations and changes in their niches	Ono et al[18]
	Yousef et al[64]
	Conboy et al[65]
	Wang et al[66]