Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function

Table 3 Improvement in high resolution esophageal manomtery and timed barium esophagram parameters in each treatment group

	PD (n = 22)
Factor	n	Pre-Treatment	Post-treatment	P value
HREM1
TBE
Height at 1 min (cm)	22	10.2 (7.0, 13.6)	8.0 (5.8, 11.0)	0.11
Width at 1 min (cm)	22	3.4 (2.5, 4.0)	2.0 (1.5, 2.5)	< 0.001
Volume at 1 min (cc)	22	67.3 (44.0, 126.2)	25.4 (14.1, 41.7)	< 0.001
Height at 5 min (cm)	20	6.5 (4.0, 10.5)	2.2 (0.00, 6.5)	0.026
Width at 5 min (cm)	20	2.7 (2.0, 3.6)	1.05 (0.00, 2.6)	< 0.001
Volume at 5 min (cc)	20	40.8 (15.5, 73.1)	4.1 (0.00, 30.2)	0.001
	LHM (n = 142)
Factor
HREM
Basal mean pressure (mmHg)	86	40.5 (27.2, 51.7)	14.5 (7.6, 22.7)	< 0.001
LES-IRP pressure (mmHg)	92	24.0 (17.5, 34.4)	7.1 (3.9, 10.7)	< 0.001
TBE
Height at 1 min (cm)	133	9.5 (7.2, 15.0)	6.7 (4.5, 10.2)	< 0.001
Width at 1 min (cm)	133	3.0 (2.5, 4.0)	2.0 (1.2, 2.5)	< 0.001
Volume at 1 min (cc)	133	71.6 (41.1, 131.9)	20.4 (6.0, 49.8)	< 0.001
Height at 5 min (cm)	131	8.0 (5.0, 12.5)	2.5 (0.00, 6.2)	< 0.001
Width at 5 min (cm)	131	2.5 (2.0, 3.7)	1.00 (0.00, 2.1)	< 0.001
Volume at 5 min (cc)	131	49.1 (15.7, 91.6)	2.7 (0.00, 21.2)	< 0.001
	POEM (n = 36)
Factor
Eckardt score	36	6.5 (5.0, 8.0)	1.00 (0.00, 2.0)	< 0.001
HREM
Basal mean pressure (mmHg)	24	38.7 (27.0, 48.7)	11.4 (8.2, 20.2)	< 0.001
LES-IRP pressure (mmHg)	26	23.6 (20.2, 33.4)	6.6 (3.3, 11.1)	< 0.001
TBE
Height at 1 min (cm)	34	9.8 (4.0, 14.5)	6.3 (2.1, 9.5)	0.01
Width at 1 min (cm)	34	3.4 (2.0, 4.4)	1.6 (0.50, 2.5)	< 0.001
Volume at 1 min (cc)	34	52.8 (37.7, 119.2)	12.8 (0.79, 47.7)	< 0.001
Height at 5 min (cm)	34	5.3 (2.5, 10.0)	2.3 (0.00, 6.9)	0.017
Width at 5 min (cm)	34	2.5 (1.5, 4.0)	0.50 (0.00, 2.0)	< 0.001
Volume at 5 min (cc)	34	25.4 (11.3, 62.8)	0.54 (0.00, 18.8)	0.003

¹HREM data not available in PD group. Values presented as Median (P25, P75) with Wilcoxon signed rank test. PD: Pneumatic dilation; LHM: Laparoscopic Heller myotomy; POEM: Peroral endoscopic myotomy; HREM: High resolution esophageal manometry; TBE: Timed barium esophagram; LES: Lower esophageal sphincter; IRP: Integrated relaxation pressure.