Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function

Table 2 High-resolution esophageal manometry and timed barium swallow findings: Univariable analysis

	PD (n = 22)		LHM (n = 142)		POEM (n = 36)
Factor	n	Summary	n	Summary	n	Summary	P value
Pre-treatment
Eckardt score	2	7.0 (7.0, 7.0)	9	6.0 (5.0, 7.0)	36	6.5 (5.0, 8.0)	0.77
HREM
Basal mean pressure (mmHg)	2	31.9 (10.6, 53.2)	86	40.5 (27.2, 51.7)	24	38.7 (27.0, 48.7)	0.89
LES-IRP pressure (mmHg)	3	29.1 (12.0, 34.5)	92	24.0 (17.5, 34.4)	26	23.6 (20.2, 33.4)	0.92
TBE
Height in 1 min (cm)	22	10.2 (7.0, 13.6)	133	9.5 (7.2, 15.0)	34	9.8 (4.0, 14.5)	0.43
Width in 1 min (cm)	22	3.4 (2.5, 4.0)	133	3.0 (2.5, 4.0)	34	3.4 (2.0, 4.4)	0.93
Volume remaining at 1 min (cc)	22	67.3 (44.0, 126.2)	133	71.6 (41.1, 131.9)	34	52.8 (37.7, 119.2)	0.44
Height in 5 min (cm)	20	6.5 (4.0, 10.5)	131	8.0 (5.0, 12.5)	34	5.3 (2.5, 10.0)	0.063
Width at 5 min (cm)	20	2.7 (2.0, 3.6)	131	2.5 (2.0, 3.7)	34	2.5 (1.5, 4.0)	0.83
Volume remaining at 5 min (cc)	20	40.8 (15.5, 73.1)	131	49.1 (15.7, 91.6)	34	25.4 (11.3, 62.8)	0.12
2-mo post-treatment
Eckardt score	4	4.5 (2.0, 6.0)	50	1.00 (0.00, 2.0)	36	1.00 (0.00, 2.0)	0.073
HREM
Basal mean pressure (mmHg)	2	22.0 (18.8, 25.1)	86	14.5 (7.6, 22.7)	24	11.4 (8.2, 20.2)	0.32
LES-IRP pressure (mmHg)	3	10.8 (10.5, 19.4)	92	7.1 (3.9, 10.7)	26	6.6 (3.3, 11.1)	0.18
TBE
Height in 1 min (cm)	22	8.0 (5.8, 11.0)	133	6.7 (4.5, 10.2)	34	6.3 (2.1, 9.5)	0.39
Width in 1 min (cm)	22	2.0 (1.5, 2.5)	133	2.0 (1.2, 2.5)	34	1.6 (0.50, 2.5)	0.28
Volume remaining at 1 min (cc)	22	25.4 (14.1, 41.7)	133	20.4 (6.0, 49.8)	34	12.8 (0.79, 47.7)	0.31
Height in 5 min (cm)	20	2.2 (0.00, 6.5)	131	2.5 (0.00, 6.2)	34	2.3 (0.00, 6.9)	0.94
Width at 5 min (cm)	20	1.05 (0.00, 2.6)	131	1.00 (0.00, 2.1)	34	0.50 (0.00, 2.0)	0.97
Volume remaining at 5 min (cc)	20	4.1 (0.00, 30.2)	131	2.7 (0.00, 21.2)	34	0.54 (0.00, 18.8)	0.98
Post - pre treatment difference
Eckardt score	-	-	7	-6.0 (-8.0, -2.0)	36	-6.0 (-7.0, -4.0)	0.75
HREM
Post-Pre basal mean pressure (mmHg)	2	-10.0 (-34.4, 14.5)	86	-25.1 (-36.8, -12.1)	24	-19.6 (-43.1, -11.9)	0.78
Post-Pre LES-IRP pressure (mmHg)	3	-9.7 (-23.7, -1.5)	92	-15.2 (-26.4, -8.3)	26	-14.2 (-24.5, -7.8)	0.60
TBE
Post-Pre height at 1 min (cm)	22	-0.90 (-5.5, 1.9)	133	-2.5 (-7.0, 0.30)	34	-2.8 (-8.5, 1.5)	0.73
Post-Pre width at 1 min (cm)	22	-1.4 (-2.0, -0.30)	133	-1.00 (-2.0, -0.20)	34	-1.5 (-2.1, 0.00)	0.79
Post-Pre volume at 1 min (cc)	22	-40.2 (-81.2, -14.1)	133	-35.8 (-101.8, -10.4)	34	-29.5 (-100.7, -0.29)	0.74
Post-Pre height at 5 min (cm)	20	-0.75 (-5.4, 0.05)	131	-4.7 (-10.0, 0.00)	34	-2.0 (-7.5, 1.9)	0.069
Post-Pre width at 5 min (cm)	20	-0.90 (-2.3, 0.00)	131	-1.5 (-2.2, -0.20)	34	-1.00 (-2.4, 0.00)	0.86
Post-Pre volume at 5 min (cc)	20	-14.0 (-45.9, -2.6)	131	-31.3 (-66.1, -5.5)	34	-17.0 (-37.7, 0.00)	0.14

Values presented as Median (P25, P75) with Kruskal-Wallis tests. PD: Pneumatic dilation; LHM: Laparoscopic Heller myotomy: POEM: Peroral endoscopic myotomy; HREM: High resolution esophageal manometry; TBE: Timed barium esophagram; LES: Lower esophageal sphincter; IRP: Integrated relaxation pressure.