Chemokine/chemokine receptor pair CCL20/CCR6 in human colorectal malignancy: An overview

doi:10.3748/wjg.v22.i2.833

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2016; 22(2): 833-841
Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.833

Table 1 Nomenclature of selected chemokines, coding chromosomal location, major function and interacting receptor

	Synonymes	Location	Major function	Receptor
CC Chemokine
CCL3	MIP-1α/LD78α	17q11.2	Inflammation	CCR1
CCL4	MIP-1β	17q12	Inflammation	CCR1
CCL4	MIP-1β	17q12	Inflammation	CCR5
CCL5	RANTES	17q12	Inflammation	CCR5
CCL19	MIP-3β/ELC/Exodus-3	9p13.3	Homing	CCR7
CCL20	MIP-3α/LARC/Exodus-1	2q36.3	Homing, Inflammation	CCR6
CCL21	6Ckine/SLC/Exodus-2	9p13.3	Homing	CCR7
CCL25	TECK/Ckβ15	19p13.2	Homing	CCR9
CXC Chemokine
CXCL8	IL-8	4q13.3	Inflammation, Angiogenesis¹	CXCR1
CXCL8	IL-8	4q13.3	Inflammation, Angiogenesis¹	CXCR2
CXCL9	MIG	4q21.1	Inflammation,	CXCR3
CXCL9	MIG	4q21.1	Angiogenesis²	CXCR3
CXCL10	IP-10	4q21.1	Inflammation,	CXCR3
CXCL10	IP-10	4q21.1	Angiogenesis²	CXCR3
CXCL11	I-TAC	4q21.1	Inflammation,	CXCR3
CXCL11	I-TAC	4q21.1	Angiogenesis²	CXCR7
CXCL12	SDF-1α/β	10q11.21	Homing	CXCR4
CXCL12	SDF-1α/β	10q11.21	Homing	CXCR7
CXCL13	BLC/BCA-1	4q21.1	Homing	CXCR5
CX₃C Chemokine
CX₃CL1	Fractalkine	16q13	Inflammation	CX3CR1
C-Chemokine
XCL1	Lymphotactin/SCM-1α	1q24.2	Homing	XCR1
XCL2	SCM-1β	1q24.2	Homing	XCR1

¹Promotor of angiogenesis;

²Inhibitor of angiogenesis.

Citation: Frick VO, Rubie C, Keilholz U, Ghadjar P. Chemokine/chemokine receptor pair CCL20/CCR6 in human colorectal malignancy: An overview. World J Gastroenterol 2016; 22(2): 833-841
URL: https://www.wjgnet.com/1007-9327/full/v22/i2/833.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i2.833