Helicobacter pylori and colorectal neoplasia: Is there a causal link?

Table 2 Published meta-analyses evaluating the relationship between Helicobacter pylori infection and the development of colorectal neoplasia

Ref.	Included studies, n	Outcome	Summary OR (95%CI)	Conclusion
Zumkeller et al[45], 2006, Germany	111	Cancer	1.4 (1.1-1.8)	Possible small increase in the risk of CRC
Zhao et al[44], 2008, China	131 (9 using IgG to detect infection status)	Cancer	1.49 (1.17-1.91)	Possible increase in risk of CRC
			1.56 (1.14-2.14) evaluating IgG as the only test indicator)
Hong et al[34], 2012, South Korea	10	Adenoma	1.58 (1.32-1.88)	Modest increase in the risk of colorectal adenoma
Wu et al[43], 2013, China	27	Adenoma	1.66 (1.39-1.97)	Positive association between H. pylori and colorectal neoplasia
		Cancer	1.39 (1.18-1.64)
Rokkas et al[42], 2013, Greece	28	Polyps	1.50 (1.26-1.79)	Modest statistically significant relationship of H. pylori with both cancer and polyps
		Cancer	1.30 (1.07-1.59)
Chen et al[46], 2013, China	22	Cancer	1.49 (1.30-1.72)	H. pylori increases the risk of CRC
Guo et al[41], 2014, China	92	Hyperplastic polyp	0.72 (0.44-1.18)	No statistical association between H. pylori and colorectal neoplasm was found, but H. pylori may increase the risk of adenoma
		Adenoma	1.83 (1.35-2.51)
		Cancer	1.08 (0.89-1.68)

¹Only case-control studies were included;

²Included only data based on East-Asian population. H. pylori: Helicobacter pylori; IgG: Immunoglobulin G; CRC: Colorectal cancer.