Integration of genome scale data for identifying new players in colorectal cancer

Table 3 Relevant studies that integrated methylation and gene expression profiles

Ref.	Case series		Genes
	Methylation	mRNA
Hinoue et al[56]	29 NOR, 125 CRC	19 couples	464 genes downregulated CIMP-H vs normal samples, 112 of them (24%) exhibit promoter hypermethylation
			12 genes downregulated and hypermethylated in non-CIMP tumors
Szmida et al[57]	12 couples	19 couples (from Hinoue et al[56], 2012)	4 ErbB-associated genes (PIK3CD, PKCΒ, ERBB4, PAK7) differentially methylated in CRC
Wang et al[58]	42 NOR, 231 CRC	26 NOR, 231 CRC	118 methylation-perturbed genes whose expression is affected by the highly variable DNA methylation sites

Couple: Tumor tissue matched with its normal colorectal mucosa; CRC: Colorectal cancer; NOR: Normal colorectal mucosa.