Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction

Figure 2 Serum alanine aminotransferase levels and histology injury score following ischemia-reperfusion. Serum alanine aminotransferase (ALT) (A) and histology injury score (B) following reperfusion were significantly higher in rats subjected to IRI compared to sham rats. Both injury markers were significantly higher in obese rats compared to lean rats. Compared to corresponding IRI groups, IPC decreased ALT levels in both lean and obese rats and decreased injury score in obese rats. Data are shown as mean ± SEM (n = 10 rat/group; lean rats, open bar; obese rats, closed bar). IRI: Ischemia-reperfusion injury; IPC: Ischemic preconditioning.