Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction

Figure 1 Bodyweight, random blood glucose, and baseline histology of high-fat/high-sucrose-fed (obese) and lean Sprague-Dawley rats. Obese Sprague-Dawley rats were significantly heavier (A) with higher random blood glucose (B) than age-matched lean rats. Baseline liver tissue sections were stained for hemotoxylin and eosin (x 40 magnification). Representative slides are displayed, and obese rats (D) showed severe mixed hepatic steatosis while lean rat livers (C) showed mild microvesicular steatosis. Data are shown as mean ± SE (n = 30 rat/group). Statistical analyses were performed using Students t-tests for body weight and random blood glucose.