miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate

Figure 5 Model of miR-30b inhibition of autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate. The expression of miR-30b, which binds the 3’-UTR of Atg12, was significantly down-regulated after HIRI. Levels of Atg12 and Atg12-Atg5 conjugate then increased and promoted autophagy, leading to apoptotic cell death. Therefore, miR-30b can inhibit autophagy to alleviate hepatic IRI by decreasing levels of Atg12-Atg5 conjugate. HIRI: Hepatic ischemia-reperfusion injury.