Role of estrogen receptor β selective agonist in ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis

Figure 7 Diarylpropionitrile inhibits collagen lattice contraction in hepatic stellate cells and decreases ET-1 induced moesin and MLC phosphorylation. A: Appearance of collagen lattices 4 h after drug treatment; B: The percentage of remaining lattice area 4 h after drug treatment (each group n = 12); C, D: Western blot analysis of ERβ protein expression in hepatic stellate cells (HSCs) (each group n = 5); E: Western blot analysis of the total and phosphorylated moesin and MLC in HSCs; F: Relative densitometric quantifications of moesin and MLC experiments (mean ± SE), with the values of the controls set to 100 DU (each group n = 5). ^aP < 0.05 vs control group; ^cP < 0.05 vs DPN group. OVX: ovariectomized; SVR: Systemic vascular resistance; DPN: Diarylpropionitrile.