Elevated serum interleukin-38 level at baseline predicts virological response in telbivudine-treated patients with chronic hepatitis B

doi:10.3748/wjg.v22.i18.4529

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2016; 22(18): 4529-4537
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4529

Table 2 Dynamics of clinical parameters in patients with chronic hepatitis B during LdT treatment

Parameters	Baseline	3 mo	6 mo	9 mo	13 mo
HBV DNA load (log₁₀ IU/mL)	8.41 (7.68-8.80)	3.79^a (3.20-5.14)	3.04^a (2.48-3.98)	2.81^a (2.48-3.10)	2.48^a (2.48-3.50)
ALT level (U/L)	117.35 (74.50-241.48)	36.00^a (23.93-85.50)	27.00^a (22.00-38.00)	27.50^a (23.00-34.25)	29.50^a (24.00-55.00)
AST level (U/L)	96.75 (57.25-176.25)	34.00^a (28.00-55.25)	26.00^a (22.00-31.25)	24.50^a (19.75-30.00)	27.00^a (22.75-43.25)
HBsAg level (IU/mL)	7821.43 (3337.23-20737.14)	4214.99^a (2034.48-10170.46)	5153.19^a (2039.45-10671.30)	4414.88^a (2317.96-10084.21)	4210.48^a (1664.73-9823.78)

Data are represented as median and interquartile range (IQR). Normal values: ALT ≤ 50 IU/L; AST ≤ 40 IU/L; HBV DNA ≤ 1.78 log₁₀ IU/mL (60 IU/mL).

^aP < 0.05 vs baseline value. The undetectable HBV DNA loads were recorded as those ≤ 60 IU/mL. CHB: Chronic hepatitis B; HBV: Hepatitis B virus; ALT: Alanine transferase; AST: Aspartate transferase; HBsAg: Hepatitis B surface antigen.

Citation: Wang HJ, Jiang YF, Wang XR, Zhang ML, Gao PJ. Elevated serum interleukin-38 level at baseline predicts virological response in telbivudine-treated patients with chronic hepatitis B. World J Gastroenterol 2016; 22(18): 4529-4537
URL: https://www.wjgnet.com/1007-9327/full/v22/i18/4529.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i18.4529