Inhibitory effect of miR-125b on hepatitis C virus core protein-induced TLR2/MyD88 signaling in THP-1 cells

Figure 1 Increased cytokine expression and decreased miR-125b expression in hepatitis C virus core protein treated THP-1 cells. THP-1 cells were treated with HCV core recombinant protein at a final concentration of 0.5, 1.0 or 5.0 μg/mL and incubated for 6, 12 or 24 h. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-10, and IL-6 in culture supernatants were analyzed by enzyme-linked immunosorbent assay. The cellular miR-125b levels were determined by real-time quantitative polymerase chain reaction. The data are representative of three experiments and shown as mean ± SEM.