Growth hormone abolishes the negative effects of everolimus on intestinal wound healing

Figure 4 Immunohistochemistry for PCNA- (A) and MPO- (B) positive cells from the anastomotic region. Treatment with everolimus alone reduced significantly the amount of PCNA-positive cells in the anastomotic region while increasing the number of MPO-positive cells, indicating a prolonged inflammation. Simultaneous treatment with hGH led to nearly normal values for PCNA- and MPO-positive cells. V: Vehicle, E: Everolimus 3.0 mg/kg, E + GH: Everolimus 3.0 mg/kg + hGH 2.5 mg/kg; V vs E, E + GH vs E, ^aP < 0.05.