Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy

Table 2 Psychometric evaluation

	Healthy subjects	C + non-HE	C + CHE	C + HE	P value
CFF	45.0 (43.0-48.6)	39.9 (39.2-41.4)	36 (33-39)	36 (35-40)	0.000
PHES	0 (-2 to 1)	-2 (-3 to -1)	-9 (-13 to -5)	-9.5 (-12 to –3)	0.000
Digit symbol	33.8 ± 18.3	28.91 ± 9.06	18.9 ± 8.8	13.4 ± 7.8	0.000
Number connection A	43.6 ± 21.1	49.5 ± 19.4	102.8 ± 66.5	148.8 ± 85.7	0.000
Number connection B	112.9 ± 39.1	147.2 ± 82.8	318.5 ± 153.03	435.7 ± 209.9	0.000
Serial dotting	62.3 ± 22.6	77.43 ± 18.1	127 ± 46.9	147.6 ± 64.3	0.000
Line tracing	95.2 ± 27.45	95.6 ± 28.6	193.8 ± 93.5	167.5 ± 37.8	0.000

Data presented as absolute frequencies, median (IQR) and mean ± SD. C: Cirrhosis; CHE: Covert hepatic encephalopathy; HE: Overt hepatic encephalopathy.