Shear wave elastography results correlate with liver fibrosis histology and liver function reserve

Table 3 Pharmacokinetics (median ± IQR) of plasma monoethylglycinexylidide (n = 14)

Variable	F0 control	F2	F3	F4	P value
	(n = 2)	(n = 3)	(n = 7)	(n = 2)
C10 min (ng/mL)	252 ± 31	197 ± 381	99 ± 105	72 ± 38	0.280
C30 min (ng/mL)	327 ± 561	268 ± 3751,2	120 ± 312,3	73 ± 203,4	0.033
C60 min (ng/mL)	274 ± 711	258 ± 3361,2	93 ± 262,3	51 ± 373,4	0.020
Cmax (ng/mL)	327 ± 56	282 ± 332	143 ± 106	82 ± 22	0.069
tmax (min)	30.0 ± 0.0	40.0 ± 20.0	30.0 ± 20.0	17.5 ± 5.0	0.120
t½max (min)	141.3 ± 110.1	151.1 ± 188.3	46.9 ± 50.2	74.9 ± 75.9	0.545
AUC (ng/mL·min)	16644 ± 31391	14421 ± 25151,2	6100 ± 22862,3	3970 ± 16703,4	0.016
Kmax (ng/mL/min)	43.7 ± 7.2	38.1 ± 83.8	17.7 ± 22.8	6.6 ± 1.5	0.358

^1,2,3,4The two groups with no common letter have a statistically significant difference. C_{10 min}, C_{30 min} and C_{60 min}: Concentrations at 10, 30, and 60 min, respectively; C_max: The maximum concentration; IQR: Interquartile range; K_max: The maximum concentration increase per unit time; t_max and t_½max: Times to the maximum and ½ of the maximum concentration; AUC: Area under the curve.